Full name: Song Yanhua

Title: Ph.D., Professor, Associate Director of Institute of Veterinary Medicine

Team: Prevention and control of rabbit epidemics

Interests:The etiology, genetic evolution, pathogenic mechanism and novel vaccine prevention and control of rabbit hemorrhagic disease virus and rotavirus. Pathogenic mechanism and immune control of bacterial diseases such as rabbit Pasteurellosis and Clostridiosis welchii.

Affiliation: Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China,

Office phone: +86-25-84390661

E-mail: songyanhua8507@126.com; 

Publications:

1. Zhiyang Ruan #, Qianqian Shao#, Yanhua Song# (co-first author), Bo Hu #, Zhiyu Fan, Houjun Wei, Yunshu Liu, Fang Wang*, Qianglin Fang*. Near-atomic structures of RHDV reveal insights into capsid assembly and different conformations between mature virion and VLP. Journal of Virology, 2024, 98(11):e0127524.

2. Mengting Wu#, Mengmeng Chen#, Rulong Qiu, Lei Ge, Zhiyu Fan, Bo Hu, Houjun Wei, Yiming Li, Fang Wang* and Yanhua Song*. Specific Detection of RHDV GI.1 and GI.2 by RT-LAMP-CRISPR/Cas12a Platform. Transboundary and Emerging Diseases. 2024, ID 3881457. 2.

3.Yanhua Song#, Gaopeng Hou#, Jonathan Diep1, Yaw Shin Ooi1, Natalia S. Akopyants, Stephen M. Beverley, Jan E. Carette, Harry B. Greenberg, Siyuan Ding*. Inhibitor of growth protein 3 epigenetically silences endogenous retroviral elements and prevents innate immune activation. Nucleic Acids Res. 2021.16;49(22):12706-12715.

4.Siyuan Ding#*; Yanhua Song# (co-first author); Kevin F.Brulois; Junliang Pan; Julia Y.Co; Lili Ren; Ningguo Feng; Linda L. Yasukawa; Liliana Sánchez-Tacuba; Jonathan E.Wosen; Elizabeth D. Mellins; Denise M. Monack; Manuel R. Amieva; Calvin J. Kuo; Eugene C. Butcher; Harry B. Greenberg*; Retinoic Acid and Lymphotoxin Signaling Promote Differentiation of Human Intestinal M Cells. Gastroenterology, 2020, 159(1): 214-226. (co-first author)

5.Yanhua Song#; Ningguo Feng#; Liliana Sanchez-Tacuba; Linda L. Yasukawa;Lili Ren; Robert H. Silverman; Siyuan Ding*; Harry B. Greenberg*; Reverse Genetics Reveals a Role of Rotavirus VP3 Phosphodiesterase Activity in Inhibiting RNase L Signaling and Contributing to Intestinal Viral Replication In Vivo. Journal of Virology, 2020, 94(9), e01952-19.

6.  Lili Ren, Siyuan Ding*, Yanhua Song (co-first author), Bin Li, Muthukumar Ramanathan, Julia Co, Manuel R. Amieva, Paul A. Khavari and Harry B. Greenberg. Profiling of rotavirus 3’UTR-binding proteins reveals the ATP synthase subunit ATP5B as a host factor that supports late-stagevirus replication. JBC 2019, doi: 10.1074/jbc.RA118.006004.

7. Mengmeng Chen, Zhiyu Fan, Bo Hu, Yanhua Song, Houjun Wei, Rulong Qiu, Weifeng Zhu, Weizhong Xu, Fang Wang. Pathogenicity of the newly emerged Lagovirus europaeus GI.2 strain in China in experimentally infected rabbits. Veterinary Microbiology, 2022, 265:109311.Lili Ren#;

8. Bo Hu; Houjun Wei; Yanhua Song; Mengmeng Chen; Zhiyu Fan; Rulong Qiu; Weifeng Zhu; Weizhong Xu; Fang Wang*; NE-kappa B and Keap1 Interaction Represses Nrf2-Mediated Antioxidant Response in Rabbit Hemorrhagic Disease Virus Infection. Journal of Virology, 2020, 94(10), e00016-20.

9. Ningguo Feng; Liya Hu; Siyuan Ding; Mrinmoy Sanyal; Boyang Zhao; Banumathi Sankaran; Sasirekha Ramani; Monica McNeal; Linda L. Yasukawa; Yanhua Song; B.V. Venkataram Prasad; and Harry B. Greenberg*; Human VP8*mAbs neutralize rotavirus selectively in human intestinal epithelial cells. Journal of Clinical Investigation, 2019, 129(9): 3839-3851.

10. Siyuan Ding*, Shu Zhu, Lili Ren, Ningguo Feng, Yanhua Song, Xiaomei Ge, Bin Li, Richard A Flavell, Harry B Greenberg*. Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells. eLife 2018;7:e39494.

11. Yanhua Song, Zhiyu Fan, Yuanyuan Zuo, Houjun Wei, Bo Hu, Mengmeng Chen, Rulong Qiu, Jiabin Xue, Fang Wang*. Binding of rabbit hemorrhagic disease virus-like particles to host histo-blood group antigens is blocked by antisera from experimentally vaccinated rabbits. Archives of Virology. 2017 Aug 5. doi: 10.1007/s00705-017-3509-8.

12. Yanhua Song, Fang Wang*, Zhiyu Fan, Bo Hu, Xing Liu, Houjun Wei, Jiabin Xue, Weizhong Xu, Rulong Qiu. Identification of novel rabbit haemorrhagic disease virus B-cell epitopes and their interaction with host histo-blood group antigens. J Gen Virol, 2016, 97, 356-365.

13. Mengmeng Chen, Yanhua Song (co-first author), Zhiyu Fan, Ping Jiang, Bo Hu, Jiabin Xue, Houjun Wei, Fang Wang*. Immunogenicity of different recombinant rabbit hemorrhagic disease virus-like particles carrying CD8+ T cell epitope from chicken ovalbumin (OVA). Virus Research, 2014,183(21):15-22. (co-first author)

14. Yanhua Song, Yefei Zhou, Yufeng Li, Xianwei Wang, Juan Bai, Jun Cao, Ping Jiang*.  Identification of B-cell epitopes in the NSP1 protein of porcine reproductive and respiratory syndrome virus. Veterinary Microbiology. 2012,155(2-4):220-229.

15. Hu Bo, Wang Fang*, Fan Zhiyu, Yanhua Song, Abrantes J, Zuo Yuanyuan, Pedro J. Esteves. Recombination between G2 and G6 strains of rabbit hemorrhagic disease virus (RHDV) in China. Arch virol. 2017,162,269-272.

16. Bo Hu, Zhiyu Fan, Fang Wang,∗, Yanhua Song, Houjun Wei, Xing Liu, Rulong Qiu, Weizhong Xu, Wanzhe Yuan, Jiabin Xue. A new variant of rabbit hemorrhagic disease virus G2-like strain isolated in China. Virus Research. 2016, 215, 20-24.

17. Xing Liu, BoHu, Fang Wang*,Yanhua Song, Zhiyu Fan, Houjun Wei, Rulong Qiu,Weizhong Xu. Molecular cloning of the rabbit interleukin 6 promoter: Functional characterization of rabbit hemorrhagic disease virus response elements in RK-13 cells. Developmental and Comparative Immunology. 65 (2016) 280-288.