Prof. Zhu Ping from National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences was invited to the Institute of Veterinary Medicine (IVM) on July 26, 2012. The topic of his lecture was “Study of CryoElectron Microscope 3-Dimensional Virus Structure”. Over 50 scientists of IVM and National Engineering Center for Veterinary Bio-products and some graduate students attended the lecture, which was chaired by IVM Director He Kongwang.
Zhu Ping, Ph.D., Tsinghua University; Postdoctoral Research Assistant, Florida State University, is now Professor of “Hundred Talents Program”, Institute of Biophysics, Chinese Academy of Sciences. Dr. Zhu Ping has long been dedicated to CryoElectron Microscopy research. During his postdoctoral research, he reported the first 3-D images of the envelope spike on SIV surface by electron tomography. After returning back to China, he first discovered that atomic model of a cypovirus built from cryo-EM structure would provide insight into the mechanism of mRNA capping. He had 22 SCI-cited papers published in international journals like Nature, Vaccine, etc.
In his lecture, Dr. Zhu Ping introduced the world-class CryoElectron Microscopy Research Platform of Institute of Biophysics, Chinese Academy of Sciences. He explained the application of 3D reconstruction, 3D average, and single particle analysis by CryoElectron Tomography through the study of HIV-1 and 3D structure of a cypovirus (CPV) from Reoviridae at near-atomic resolution. Dr. Zhu Ping showed the 20-200 nanometer-sized virus structure by CryoElectron Microscopy, which gave all the participants a brand-new visual impact.
CryoElectron Microscopy has been developed since 1970s and is more and more widely used in the study of biomacromolecule structures. It provides a visual approach for the study of virus structure and function and is of great significance to the study and selection of major animal epidemic structural protein. Therefore, it is becoming one of the cutting-edge technologies of veterinary medicine both home and abroad.
Dr. Zhu Ping’s detailed and vivid lecture aroused great research interest of JAAS scientists. He also wished to further enhance the significance of CryoElectron Microscopy through perfect combination of morphology and function study. The IVM of JAAS will carry out initial cooperation with Dr. Zhu Ping in the study of P1 agent in the near future.